May 16, 2016 nrg oncology rtog 6 a randomized phase ii study of individualized combined modality therapy for stage iii nonsmall cell lung cancer nsclc. Radiation therapy with or without chemotherapy in treating. However, it should have the same value for all image files for the same patient in the exchange file set. Calgb 30610 rtog 0538 limited small cell 45 gy bid 3 weeks 61. It would be possible to simply convert the emami dose limits to any fractionation scheme using this. This site will allow users to register a patient or enter case form data directly to a nrg rtog study twentyfour 24 hours a day, seven 7 days a week. Nrgalias broadcasts rtog clinical trials protocol table. For rtog 3d qa center purposes, it should be the patients name or some other identifier which the submitting institution can use to identify the data set in question should the 3d qa center have questions about the case. Additional definitions beyond the recist guidelines. Because statistically significant advantages for this experimental approach could not be defined for all end. Patients with the following pathology findings may be treated with pelvic radiation with or without weekly cisplatin at the treating physicians discretion. Clinical trials southeast radiation oncology group, p. Radiation oncologyrtog trials wikibooks, open books for an.
From wikibooks, open books for an open world rtog 0631 assessed the feasibility and safety of spine radiosurgery srs for localized spine metastases in a cooperative group setting. It is intended to be used only in conjunction with institutionspecific irb approval for study entry. Nrg oncology rtog 6 a randomized phase ii study of. Radiation oncologyrtog trials8531 wikibooks, open books. Stereotactic body radiation therapy for early stage nonsmall cell. Radiation therapy oncology group rtog 0618 a phase ii trial. This protocol was designed and developed by the radiation therapy oncology group rtog of the american college of radiology acr. This is an ascii program runs in a winterm or xterm window with a keyboard interface and commands, in windows a command prompt window and is invoked with the flag d followed by the directory where the rtog files are for the particular patient. This randomized phase iiiii trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with highrisk malignant salivary gland tumors that have been removed by surgery. Rtog 0915, a randomized phase ii study comparing 2 stereotactic body. A phase iii trial of adjuvant chemotherapy following. A randomized phase 2 study comparing 2 stereotactic body radiation.
No other use or reproduction is authorized by rtog nor does rtog assume. Rtog 0915 dosimetric criteria in peripheral lung cancer patients treated with. Mar 07, 2003 combination chemotherapy and radiation therapy withwithout surgery in patients with stage iiiii bladder cancer the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. However, it is imperative to apply these protocols to patients from the areas of china where npc is endemic, and further assess longterm survival and late toxicities. Survival and toxicities of imrt based on the rtog protocols. This questionnaire is intended to evaluate your understanding of the protocol. About 60 percent of the adults enrolled in clinical trials are women. The decision to add weekly cisplatin for these patients is at the treating physicians discretion.
The rtog 0225 and rtog 0615 protocols for npc provided good treatment outcomes and acceptable rtrelated toxicities in patients from the nonendemic regions 12. Videtic and others published radiation therapy oncology group rtog protocol 0915. Pelvic irradiation with concurrent chemotherapy versus pelvic. Stereotactic radiosurgery is well established for the treatment of intracranial neoplasms but its use for lung tumors is novel. A phase iii study comparing combined external beam radiation and transperineal interstitial permanent brachytherapy with brachytherapy alone for selected patients with intermediate risk prostatic carcinoma. This project was supported by grants u10ca21661, u10ca180868, u10ca180822, u10ca37422, and u24ca180803 from the national cancer institute nci. Implementation of radiosurgery and sbrt requires a. Because rtog 0915 report demands rapid dose falloff beyond the target, the dose to the gtv was always. Dvh of the gtv, ptvgtv, lung and cw after eqd2 conversion.
A randomized phase ii study comparing 2 stereotactic body radiation therapy sbrt schedules for medically inoperable patients with stage i. The severity of skin toxicity is dependent on volume of tissue treated, total daily dose, fractionation, dose distribution, and certain individual factors. Twentythree patients with biopsyproven lung tumors were recruited. No other use or reproduction is authorized by rtog nor does rtog assume any. Rtog 0915 nrg oncology rtog 0915 ncctg n0927 a randomized phase ii study comparing 2 stereotactic body radiation therapy sbrt schedules for medically inoperable patients with stage i peripheral nonsmall cell lung cancer document history 3614 versionupdate date broadcast date amendment 4 march 6, 2014 march 19, 2014. The radiation therapy oncology group has completed 2 trials rtog 0614 and 0933 aimed at reducing the toxicity of wbrt.
Pragmatic phase iii randomized trial of proton vs photon therapy for patients with nonmetastatic breast cancer receiving comprehensive nodal radiation. Radiobiological modeling of two stereotactic body radiotherapy. During a course of radiation temporary skin reactions are common and vary from mild erythema to brisk, moist desquamation. Lung, breast, prostate and colon cancers have the highest number of clinical trials dedicated to them more than 40 percent of the total number of trials. Rtog 0614 was a randomized trial of wbrt versus wbrt and memantine in patients with brain metastases and showed better cognitive function over time in the memantine group. Assessment of monte carlo algorithm for compliance with rtog. A radiotherapy comparative effectiveness radcomp consortium trial. Pdf using monte carlo simulation and a realistic patient model, it is shown that the volume of healthy.
A phase ii study of preoperative preop chemoradiotherapy crt utilizing imrt in combination with capecitabine c and oxaliplatin o for patients with locally advanced rectal cancer, international journal of radiation oncology biology physics on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your. Monte carlo algorithms, lung sbrt, rtog 0915 compliance criteria. Videtic and others published longterm followup on nrg oncology rtog 0915 ncctg n0927. Rtog is funded by national cancer institute grant numbers. Sixtyfive institutions were credentialed with spine phantom dosimetry and igrt compliance. Orcutt and others published dose escalation using pet imaging for nsclc while maintaining rtog 091508 criteria find, read and cite all the research you need on. A prior radiation therapy oncology group rtog clinical trial in anaplastic oligodendroglioma suggested a progressionfree survival. Rtog 0915 12gy x 4 vs 30gy x 1 showed equivalent control results 97% lc in both arms. Sep 21, 2015 this is an area of considerable debate and the topic of an ongoing north american cooperative randomized trial radiation therapy oncology group rtog 0815 for patients with intermediaterisk prostate cancer clinical stage t2b or t2c, gs of 7, or psa of 1020 ngml. The radiation therapy oncology group rtog conducted the first multicenter, north american. The large multi institutional studies from the rtog 0236, 08 and 0915.
Patients with prostate cancer and indications for postoperative rt should be considered for combined rt and hormonal manipulation. If we apply these corrections to convert our mc computed ribs dose, the dose to water. A phase iii trial of adjuvant chemotherapy following chemoradiation as primary treatment for locally advanced cervical cancer compared to chemoradiation alone. Reduced fractionation in lung cancer patients treated with curative. A randomized phase 2 study comparing 2 stereotactic body radiation therapy. Combination chemotherapy and radiation therapy withwithout.
Rtog 0538calgb 30610 protocol student doctor network. Radiation therapy oncology group rtog protocol 0915. Looks like it has been removed from the rtog website. Conversion from hounsfield units to material composition. Many more patients are enrolled in clinical trials sponsored by other groups. Rtog 0236 a phase ii trial of sbrt in the treatment of patients with medically inoperable stage iii nonsmall cell lung cancer rtog 0618 a phase ii trial of sbrt in the treatment of patients with operable stage iii nonsmall cell lung cancer rtog 08 seamless phase iii study of sbrt for early stage, centrally. Dose tolerance limits and dose volume histogram evaluation for. Secondary analysis of rtog 9508, a phase 3 randomized trial. Randomised trial of hyperfractionation versus conventional fractionation in t2 squamous cell carcinoma of the vocal cord rtog 9512 eortc 22992. Oct 21, 2016 we would like to thank the nrg oncology rtog staff including minhee won, kathryn okrent, sandrine geinoz, barbara kaiser, and denise manfredi for their outstanding work on this clinical trial. Pdf dose escalation using pet imaging for nsclc while.
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